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BOOK SUMMARY :

Targeting the bodys biological clock may be a potential strategy for treating cancer a new study shows two compounds that target components of the circadian clock killed several types of cancer cells in the lab and slowed the growth of brain tumors in mice without harming healthy cells the note citations are based on reference standards however formatting rules can vary widely between applications and fields of interest or study the specific requirements or preferences of your reviewing publisher classroom teacher institution or organization should be applieddividing cells including human cancers organize processes necessary for their duplication according to circadian time recent evidence has shown that disruption of central regulation of circadian rhythms can increase the rate at which a variety of cancers develop in rodents in order to study evidence from population based in vivo and in vitro studies have implicated circadian rhythms in the control of cancer and are consistent with the hypothesis that specific components in the host circadian timing system regulate tumor growth factors regulating tumor growth share the capacity to modulate peripheral clocks the cell cycle and energy metabolism purpose and design to review briefly the growing body of published data about circadian variation in cytotoxic drug metabolism and tissue sensitivity to chemotherapeutic agents the suggestion that toxicity may be reduced and anticancer efficacy improved by administering antineoplastic agents at carefully selected times of the day was assessed

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